Effect of adrenergic beta-receptor blocker on epinephrine-induced cardiac arrhythmias during halothane anaesthesia.
نویسندگان
چکیده
RESULTS OF INVESTIGATIONS performed on animals indicate that halothane anaesthesia increases the sensitivity of the myocardial tissues to epinephrine. 1-s In man, ventricular arrhythmias may follow the use of the epinephrine. ~'7 This investigation was undertaken to study the usefulness of an adrenergic/3-receptor blocking agent (Pronethalol)f in preventing and/or correcting cardiac arrhythmias produced by epinephrine infusion during halothane anaesthesia.
منابع مشابه
Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs.
Beta 2 as well as beta 1 adrenoceptors have been recognized in the heart of vertebrates. They mediate a positive chronotropic action of catecholamines. We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs. The arrhythmogenic dose (AD) of epinephrine was increased in the presence of l-metoprolol, a selective be...
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متن کاملSelective adrenergic beta-receptor blockade in the prevention of adrenaline-evoked ventricular arrhythmias in dogs anaesthetized with halothane in oxygen.
The effect of selective beta-receptor blockade on adrenaline-evoked ventricular arrhythmias was studied in atropinized dogs anaesthetized with halothane in oxygen. Cardiac beta-receptors were selectively blocked with ICI 50172, while the peripheral vascular beta-receptors were selectively blocked with H 35/25. ICI 50172 prevented adrenaline-evoked ventricular arrhythmias and the increase in sin...
متن کاملComparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats.
BACKGROUND Because the relative efficacy of antiarrhythmic agents on halothane-epinephrine arrhythmias has not been well characterized, this study was undertaken to comparatively evaluate the antiarrhythmic action of Na(+)-, K(+)- and Ca(2+)-channel blockers on epinephrine-induced ventricular arrhythmias during halothane anesthesia in rats. METHODS Rats were anesthetized at random with either...
متن کاملEffect of oxprenolol on adrenaline-evoked ventricular arrhythmias in dogs anaesthetized with halothane in oxygen.
The effect of oxprenolol (CIBA 39,089-Ba), a recently introduced adrenergic betareceptor antagonist, on adrenaline-evoked ventricular arrhythmias was studied in atropinized dogs anaesthetized with halothane in oxygen. The anti-arrhythmic activity of oxprenolol was due to specific blockade of beta-receptors. The block produced was surmountable in nature and larger doses of adrenaline re-evoked v...
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ورودعنوان ژورنال:
- Canadian Anaesthetists' Society journal
دوره 13 3 شماره
صفحات -
تاریخ انتشار 1966